Forschungsbericht 1999-2000   
WWU-Logo Institut für Zellbiologie
Von-Esmarch-Str. 56
48149 Münster
Tel. (0251) 83-58617
Fax: (0251) 83-58616
e-mail: vestweb@uni-muenster.de
WWW: http://www-ifi.uni-muenster.de/Dokumente/ZMBE/institute/index.html

Direktor: Prof. Dr. rer. nat. Dietmar Vestweber

 
 
 
[Pfeile  gelb] Forschungsschwerpunkte 1999 - 2000
Fachbereich 05 - Medizinische Fakultät
Institut für Zellbiologie
Einwanderung von Leukozyten in Entzündungsherde
 


Ausgewählte Publikationen

Veröffentlichungen:

M. Steegmaier, A. Levinovitz, S. Isenmann, E. Borges, M. Lenter, H. Kocher, B. Kleuser and D. Vestweber: The E-selectin-ligand ESL-1 is a variant of a receptor for fibroblast growth factor.
Nature 373, 615-620 (1995)

E. Borges, W. Tietz, M. Steegmaier, T. Moll, R. Hallmann, A. Hamann, and D. Vestweber: PSGL-1 on T helper 1 but not on T helper 2 cell binds to P-selectin and supports migration into inflamed skin.
J. Exp. Med. 185, 573-578 (1997)

F. Austrup, D. Vestweber, E. Borges, M. Löhning, R. Bräuer, R. Hallmann, A. Scheffold, A. Radbruch, and A. Hamann: P- and E-selectin mediate recruitment of T helper 1 but not of T helper 2 cells into inflamed tissues.
Nature 385, 81-83 (1997)

E. Borges, R. Eytner, T. Moll, M. Steegmaier, MA Campbell, K. Ley, H. Mossmann, and D. Vestweber: The P-selectin glycoprotein ligand-1 is important for recruitment of neutrophils into inflamed mouse peritoneum.
Blood 90, 1934-1942 (1997)

S.M. Morgan, U. Samulowitz, L. Darley, D.L. Simmons, and D. Vestweber: Biochemical characterization and molecular cloning of a novel endothelial specific sialomucin.
Blood, 93: 165-175 (1999)

T. Marquardt, T. Brune, K. Lühn, P. Zimmer, C. Körner, L. Fabritz, N. van der Werft, J. Vormoor, H.H. Freeze, F. Louwen, B. Biermann, E. Harms, K. von Figura, D. Vestweber, and H.G. Koch: A new patient with Leukocyte Adhesion Deficiency (LAD) II Syndrome.
J. Pediatr. 134: 681-688 (1999)

T. Marquardt, K. Lühn, G. Srikrishna, H.H. Freeze, E. Harms, and D. Vestweber: Correction of Leukocyte Adhesion Deficiency Type II with oral fucose.
Blood, 94:3976-3985 (1999)

K. Ebnet, C.U. Schulz, M.-K. Meyer-zu Brickwedde, G.G. Pendl, and D. Vestweber: Junctional Adhesion Molecule (JAM) interacts with the PDZ domain containing proteins AF-6 and ZO-1.
J. Biol. Chem. 275:27979-27988 (2000)

M.-C. Huang, 0. Zöllner, T. Moll, P. Maly, A.D. Thall, J.B. Lowe, and D. Vestweber: P selectin glycoprotein ligand-1 and E-selectin ligand-1 are differentially modified by fucosyltransferases Fuc-TIV and Fuc-TVII in mouse neutrophils.
J. Biol. Chem. 275:31353-31360 (2000)

K. Lühn, T. Marquardt, E. Harms, and D. Vestweber: Discontinuation of fucose therapy in LADII causes rapid loss of selectin ligands and rise of leukocyte counts.
Blood 97:330-332 (2001)

K. Lühn, M.K. Wild, M. Eckhardt, R. Gerardy-Schahn, D. Vestweber: The defective gene in leukocyte adhesion deficiency 11 codes for a GDPfucose transporter.
Nat. Genet. 28:69-72 (2001)

M.K. Wild, M.-C. Huang, U. Schulze-Horsel, P.A. van der Merwe, D. Vestweber: Affinity, kinetics and thermodynamics of E-selectin binding to E-selectin ligand-1.
J. Biol. Chem. 276:31602-31612 (2001)

K. Ebnet, A. Suzuki, Y. Horikoshi, T. Hirose, M.-K. Meyer-zu-Brickwedde, S. Ohno, D. Vestweber: The cell polarity protein ASIP/PAR-3 directly associates with Junctional Adhesion Molecule (JAM).
EMBO J. 20: 3738-3748 (2001)

G. Brachtendorf, A. Kuhn, U. Samulowitz, R. Knorr, E. Gustaffson, A.J. Potocnik, R. Fässler, D. Vestweber: Early expression of endomucin on endothelium of the mouse embryo and on putative hematopoetic clusters in the dorsal aorta.
Dev. Dynam. 222:410-419 (2001)

I. Nasdala, K. Wolburg-Buchholz, H. Wolburg, A. Kuhn, K. Ebnet, G. Brachtendorf, U. Samulowitz, B. Kuster, B. Engelhardt, D. Vestweber and S. Butz: A transmembrane tight junction protein selectively expressed on endothelial cells and platelets.
J. Biol. Chem. in press (2002)

U. Samulowitz, A. Kuhn, G. Brachtendorf, R. Nawroth, A. Braun, A. Bankfalvi, W. Böcker, and D. Vestweber: Human endomucin: distribution pattern, expression on high endothelial venules and decoration with the MECA-79 epitope.
Am. J. Pathol. in press (2002)

 
 
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Hans-Joachim Peter
EMail: vdv12@uni-muenster.de
HTML-Einrichtung: Izabela Klak
Informationskennung: FO05BOA04
Datum: 2002-05-08